THE CURRENT STATE OF PANCREATIC ISLET TRANSPLANTATION
نویسندگان
چکیده
منابع مشابه
[Current status of pancreatic islet transplantation].
DM (diabetes mellitus) is a metabolic disorder of either absolute or relative insulin deficiency. Optimized insulin injections remain the mainstay life-sustaining therapy for patients with T1DM (Type I DM) in 2006; however, a small subset of patients with T1DM (approx. 10%) are exquisitely sensitive to insulin and lack counter-regulatory measures, putting them at higher risk of neuroglycopenia....
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BACKGROUND No formulation of exogenous insulin available to date has yet been able to mimic the physiological nictemeral rhythms of this hormone, and despite all engineering advancements, the theoretical proposal of developing a mechanical replacement for pancreatic beta cell still has not been reached. Thus, the replacement of beta cells through pancreas and pancreatic islet transplantation ar...
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Treatment for, and the prognosis of, type-1 diabetes mellitus (T1DM) has progressed dramatically during the last century, but the disease remains a major cause of morbidity and mortality. Although precise fi gures are not available, over 1 million United States citizens currently live with the disease, with approximately 30,000 new cases diagnosed in the US each year. The total number of people...
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457 ABSTRACT: Advances in pancreatic islet transplantation for the treatment of type 1 diabetes have occurred in the past decade. Successful transplantation using the Edmonton protocol has achieved glycemic stability and insulin independence in many recipients. However, the effect of islet transplantation on secondary complications of diabetes is still not clearly understood. The UBC Islet Tran...
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Low-number transplantation of pancreatic islets into the livers of diabetic rats leads to transformation of the downstream liver acini into clear-cell foci of altered hepatocytes (FAHs). These FAHs correspond to the glycogen-storing (clear-cell) phenotype of hepatocellular preneoplasias and develop into hepatocellular adenomas (HCAs) and hepatocellular carcinomas (HCCs) within 6 to 24 months. I...
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ژورنال
عنوان ژورنال: Japanese Journal of Transfusion and Cell Therapy
سال: 2016
ISSN: 1881-3011,1883-0625
DOI: 10.3925/jjtc.62.635